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While short-term glucocorticoid steroid treatment for DMD is beneficial, the effects of long-term treatment on muscle strength and function are not well understood. Therefore, the present study was conducted to test the hypothesis that the long term treatment of DMD with glucocorticoid reduces hypertrophy and increases bone mass of the femur compared to DMD alone and that this effect was not significantly different between the different steroid groups. The results showed that a 3-month duration of long-term glucocorticoid treatment of DMD completely reversed the hypertrophy of the femur compared to both 1 and 2 months of DMD. Furthermore, 2 years of long-term glucocorticoid treatment of DMD significantly increased total bone mineral density compared to DMD alone. This study provides support for the hypothesis that a long term treatment with glucocorticoid has therapeutic effects on skeletal muscle in humans.

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